A halogen-bonding-catalyzed Michael addition reaction

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A halogen-bonding-catalyzed Michael addition reaction† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc07175b

Only a few studies on the use of halogen bonding in catalysis have been published so far. Herein, (benz)imidazolium-based halogen bond donors are used as catalysts in a Michael addition reaction. The most potent catalyst, a rigid atropisomer featuring two iodobenzimidazolium moieties, provided a rate acceleration versus a reference compound of ca. 50.

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Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction.

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ژورنال

عنوان ژورنال: Chemical Communications

سال: 2017

ISSN: 1359-7345,1364-548X

DOI: 10.1039/c7cc07175b